Evaluating endophenotypes for bipolar disorder
نویسندگان
چکیده
منابع مشابه
Bipolar disorder - from endophenotypes to treatment.
INTRODUCTION There are a lot of unresolved issues associated with the classification, diagnosis, clinical management and understanding of the underlying pathogenic mechanisms of bipolar affective disorder. AIM To search for discrete endophenotypes in BAD. SUBJECTS AND METHODS We studied various bipolar I and II and recurrent depression patient samples and healthy controls using descriptive ...
متن کاملNeurocognitive endophenotypes for bipolar disorder identified in multiplex multigenerational families.
CONTEXT Although genetic influences on bipolar disorder are well established, localization of genes that predispose to the illness has proven difficult. Given that genes predisposing to bipolar disorder may be transmitted without expression of the categorical clinical phenotype, a strategy for identifying risk genes is to identify and map quantitative intermediate phenotypes or endophenotypes. ...
متن کاملDiagnostic specificity of neurophysiological endophenotypes in schizophrenia and bipolar disorder.
BACKGROUND The utility of an endophenotype depends on its ability to reduce complex disorders into stable, genetically linked phenotypes. P50 and P300 event-related potential (ERP) measures are endophenotype candidates for schizophrenia; however, their abnormalities are broadly observed across neuropsychiatric disorders. This study examined the diagnostic efficiency of P50 and P300 in schizophr...
متن کامل[Emotion endophenotypes in bipolar and schizophrenic disorders].
Because of its proximity to the vulnerability model hypotheses and its correlation to functional outcome, emotional processing has emerged as a major topic of research in bipolar as well as schizophrenia disorders. By experimental necessity, the somewhat vague notion of emotion has been parceled into several dimensions. Thus, the aptitude to perceive and decrypt emotional stimuli has been artif...
متن کاملNeurophysiological endophenotypes across bipolar and schizophrenia psychosis.
The search for liability genes of the world's 2 major psychotic disorders, schizophrenia and bipolar disorder I (BP-I), has been extremely difficult even though evidence suggests that both are highly heritable. This difficulty is due to the complex and multifactorial nature of these disorders. They encompass several intermediate phenotypes, some overlapping across the 2 psychotic disorders that...
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ژورنال
عنوان ژورنال: International Journal of Bipolar Disorders
سال: 2021
ISSN: 2194-7511
DOI: 10.1186/s40345-021-00220-w